Effect of selenazofurin on influenza A and B virus infections of mice
Identifieur interne : 002376 ( Main/Exploration ); précédent : 002375; suivant : 002377Effect of selenazofurin on influenza A and B virus infections of mice
Auteurs : Robert W. Sidwell [États-Unis] ; John H. Huffman [États-Unis] ; Evan W. Call [États-Unis] ; Hassan Alaghamandan [États-Unis] ; P. Dan Cook [États-Unis] ; Roland K. Robins [États-Unis]Source :
- Antiviral Research [ 0166-3542 ] ; 1986.
English descriptors
- Teeft :
- Agents chemother, American society, Antitumor activity, Antiviral, Antiviral activity, Antiviral agent, Body temperature, Broad spectrum, Cancer chemotherapy, Cell culture, Drug dosage, Final treatment, Infectious virus, Infectious virus titers, Influenza, Influenza mice, Influenza virus, Influenza virus infections, Influenza viruses, Intraperitoneal treatment, Lung consolidation, Lung consolidation scores, Lung homogenate, Lung score, Lung scores, Mice compound dosage, Mouse, Normal controls, Obvious signs, Pergamon press, Personal communication, Present studies, Rectal, Rectal temperature, Rectal temperatures, Ribavirin, Robin, Selenazofurin, Single time, Single treatment, Survival time, Titer, Total host, Toxic effects, Toxicity, Toxicity control mice, Virus, Virus control animals, Virus controls, Virus exposure, Virus infections, Weight mice.
Abstract
Abstract: The inhibitory effects of selenazofurin and ribavirin on influenza A and B virus infections in mice were compared. Both compounds, when administered intraperitoneally (i.p.), reduced lung consolidation and prolonged mean day of death, but ribavirin more effectively increased survivor number and lowered lung viral hemagglutinin (HA) titers. Lung HA titers often increased in selenazofurin-treated animals. To determine the most appropriate i.p. treatment schedule, influenza A virus-infected mice were treated once, twice or thrice daily for 7–9 days, or once only. Treatment once daily for 9 days beginning 4 h pre-virus exposure, for 3 days beginning 24 h post-virus exposure, or once only 48 h post-virus exposure was most effective. Body temperature, which usually declined during infection, increased to near-normal levles in animals treated with selenazofurin, especially in animals treated a single time or for 3 days with high dose levels. Selenazofurin was well tolerated at a dose of 50 mg/kg administered twice daily, and at 400 mg/kg administered once only. Rectal temperatures temporarily declined following every other day treatment with 400 mg/kg.
Url:
DOI: 10.1016/0166-3542(86)90016-1
Affiliations:
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Both compounds, when administered intraperitoneally (i.p.), reduced lung consolidation and prolonged mean day of death, but ribavirin more effectively increased survivor number and lowered lung viral hemagglutinin (HA) titers. Lung HA titers often increased in selenazofurin-treated animals. To determine the most appropriate i.p. treatment schedule, influenza A virus-infected mice were treated once, twice or thrice daily for 7–9 days, or once only. Treatment once daily for 9 days beginning 4 h pre-virus exposure, for 3 days beginning 24 h post-virus exposure, or once only 48 h post-virus exposure was most effective. Body temperature, which usually declined during infection, increased to near-normal levles in animals treated with selenazofurin, especially in animals treated a single time or for 3 days with high dose levels. Selenazofurin was well tolerated at a dose of 50 mg/kg administered twice daily, and at 400 mg/kg administered once only. 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